Factor VIII manufactured from plasma—the ups and downs, and the up again: a personal journey—part 2: aspects of factor VIII manufacture from plasma

Despite the advances in the manufacture of plasma derived FVIII (pd-FVIII), there has been practically no improvement in the yield of biological activity over the past 20 years, with 80% of the activity in the donated plasma being lost over the process. In this review, I look back on the decades of scientific progression of pd-FVIII development, including 40 years of personal involvement, with the intention of proposing routes to improved understanding and manufacture.