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G-CSF in stem cell mobilization: new insights, new questions

   
@article{AOB3928,
	author = {Andrea M. Patterson and Louis M. Pelus},
	title = {G-CSF in stem cell mobilization: new insights, new questions},
	journal = {Annals of Blood},
	volume = {2},
	number = {5},
	year = {2017},
	keywords = {},
	abstract = {In this article, Bernitz and colleagues (1) utilize a lineage tracing mouse model to show that G-CSF selectively mobilizes quiescent non-dividing hematopoietic stem cells (HSC) from bone marrow (BM) to peripheral blood (PB) and that G-CSF administration does not induce HSC cycling/proliferation. Mobilized non-dividing HSC can return to BM, again without dividing. Moreover, the non-dividing HSC represent the true long-term repopulating cells, and those HSC left in BM after mobilization, while expressing phenotypic markers of HSC, do not in fact have repopulating capacity. (Summarized in Figure 1)},
	issn = {2521-361X},	url = {https://aob.amegroups.org/article/view/3928}
}